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KMID : 0387820150220020186
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Clinical Pediatric Hematology-Oncology
2015 Volume.22 No. 2 p.186 ~ p.189
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A Case of Long-term Survival with Autologous Recovery after Double Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia
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Lee Hyoung-Jin
Choi Jung-Yoon
Hong Che-Ry
Lee Ji-Won
Kang Hyoung-Jin
Park Kyung-Duk
Shin Hee-Young
Ahn Hyo-Seop
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Abstract
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A 1.1 year old boy was admitted to the Seoul National University Children’s Hospital because of incidental findings of hepatosplenomegaly, skin lesion and multiple intra-abdominal lymphadenopathies. Anemia and thrombocytopenia were found based on the initial complete blood count (CBC) measurements. Because of bicytopenia and hepatosplenomegaly, bone marrow examination was performed which revealed hypercellular marrow with increased monocytes and granulopoiesis. The hemoglobin F level was high for his age, and monocyte production was increased. The patient was diagnosed with juvenile myelomonocytic leukemia at the age of 1.2 years. Chemotherapy with cytarabine, etoposide, vincristine, and isotretinoin was initiated. After 6 cycles of chemotherapy, the CBC normalized. He underwent double cord blood transplantation (dCBT), but chimerism studies showed autologous recovery. However, he did not show relapse during the 5 years post-transplant during which he received isotretinoin. He is surviving disease-free 9 years after dCBT.
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KEYWORD
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Juvenile myelomonocytic leukemia, Doule cord blood transplantation, Autologous recovery, Outcome
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